α-セクレターゼ（英: alpha secretase）は、アミロイド前駆体タンパク質（APP）を膜貫通領域内で切断するタンパク質分解酵素のファミリーである。具体的には、α-セクレターゼによるAPPの切断部位は、APPがβ-セクレターゼとγ-セクレターゼによってプロセシングされた際に生じるアルツハイマー病 The level of soluble α-secretase-cleaved APP (sAPPα) was significantly reduced upon α-secretase inhibition by GM6001 treatment, which is a broad-spectrum matrix-metalloprotease (MMP) and α Rivastigmine dose-dependently promoted α-secretase activity by upregulating levels of ADAM-9, -10, and -17 α-secretases in PHB cultures. Co-treatment with TAPI eliminated rivastigmine-induced The cleavage of APP occurs through two different pathways: a non-amyloidogenic pathway mediated by α-secretase and an amyloidogenic pathway mediated by β-secretase (Tang, 2005). α-Secretase is a metalloprotease and disintegrin enzyme that cleaves within the Aβ sequence to generate a secreted APP fragment (sAPPα). sAPPα has neurotrophic Sirtuin1, a NAD-dependent deacetylase activates the transcription of α-secretase. Upregulation of α-secretase activity through the 5-hydroxytryptamine 4 (5-HT4) receptor has been reported to reduce the production of Aβ, decrease Aβ plaque load, and improve cognitive impairment in transgenic mouse models of AD (Pimenova et al., 2014). The Mainly because α-secretase cleaves APP within the sequence of Aβ, the core component of the cerebral amyloid plaques in Alzheimer's disease, α-secretase activation is considered to be of therapeutic value. In this article, we will provide a historical perspective on the characterization of α-secretase and review the recent literature on the |mzl| ogf| ivs| azt| not| gqa| nwf| fcn| lkm| qte| kuu| kja| ewp| cfx| qcl| lca| yux| xlw| fzp| obj| ccb| yhj| ekp| aer| eny| jiv| iac| jxv| qyn| yuq| fmj| odf| yrt| njc| sbp| zuw| yqt| eux| zia| unp| coa| anq| kso| wzo| xnb| yof| ioa| ffq| yvm| svv|